Understanding Cannabinoids: CBN vs CBD
While there are many cannabinoids that may enhance the therapeutic effects of hemp products, the most common renowned product is the phytochemicals in the Cannabis genus that contain the tetrahydrocannabinol or THC. This is the substance that is responsible for all of the psychoactive effects of cannabis. CBD has long been associated with the variety that offers up the best help benefits without offering up the high that the THC gives to users.
While the CBD may not be the feature that is in all of the hemp products, it’s a by-product of the THC. Hemp Genix, Wholesale CBD Oil in Clio, has 80% purity compared to competitors at 17%-40%. The CBN doesn’t bind to the body’s cannabinoid receptors like the THC does. It’s long been known to give a stronger sedative effect when it’s used in combination with the THC.
At Hemp Genix, all of our products are made with 100 percent USA, Zero THC and 80 percent purity Wholesale full-spectrum CBD oil in Clio. This is carefully derived from a variety of cultivars of hemp which contain an abundance of cannabinoids.
A lot of people are very familiar with CBD or Cannabidiol. This is found in highly concentrated amounts in a variety of products. However, there are lots of cannabinoids that are found in hemp. These have shown a variety of benefits in studies. All of our products offer you full-spectrum hemp oil. This also includes all of our cannabinoids that are found in the plant. We don’t want you to miss out on any of the benefits.
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This is the most abundant cannabinoid in the hemp oil. It makes up 90 percent of the content of cannabinoid. It’s non-psychoactive and the focus is on how it benefits the body via the hemp oil. It has minimal affinity for CB1 or CB2 receptors. The main focus on interaction is in the endocannabinoid system and it acts as an indirect antagonist toward the cannabinoid antagonists. This, in turn, may allow the CBD to temper the high that is caused through the THC. Wholesale CBD Oil in Clio from Hemp Genix are over 80 percent pure and CBD makes up the majority of the Oils weight. Industry averages and nearly all of the other products with cannabinoids and brands average in at 17 to 40 percent purity.
What’s The Difference Between CBD And CBN?
Cannabis has a number of cannabinoids in which the most abundant are the levels of THC. There are 9 tetrahydrocannabinol as well as CBD and CBN. This is the active ingredient that makes you high. The THC is in the plant and the CBD is the precursor and the CBN is the metabolite of the THC. As the cannabis ages, the THC level breaks down into the CBN.
This also leads researchers to believe that the CBD might give some protection against ecstasy-derived neurotoxins or long-term depletion of the serotonergic receptions. While this is still speculation, it’s investigating further. The CBD is usually present in significant enough quantities in such products as hashish or cannabis resins. However,r it’s also in the herbal cannabis referred to as skunk in smaller amounts.
Overall, the CBN is a great cannabinoid that offers up a varied range of therapeutic applications that work together with the rest of the “team” in order to offer up the best possible results. Clearly, more clinical trials are required to see how else it can benefit patients.
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The Department of Justice could crack down on adult-use marijuana, or what's referred to as "recreational marijuana," and enforce federal law regulating cannabis as an illegal substance, the Trump administration said during a briefing on Thursday.
White House Press Secretary Sean Spicer, during his daily press briefing, said the Department of Justice will be the lead on what Spicer referred to as "greater enforcement" of federal law concerning adult-use marijuana. The Justice Department's new head, former Alabama Senator Jeff Sessions, is staunchly opposed to marijuana legalization.
Medical marijuana, Spicer said, is safe from enforcement because of the Rohrabacher-Farr Amendment, which prohibits the DOJ from spending money to prevent states from implementing medical marijuana laws, and because President Trump "understands" how patients with terminal illnesses find "comfort" with medical cannabis. Spicer said Trump and the DOJ have drawn a line in the sand: medical marijuana on one side and adult-use on the other. The White House says adult-use marijuana would exacerbate the opioid epidemic, which is killing 40,000 Americans a year, according the Center for Disease Control. Studies have found that legal marijuana could help stem the opioid crisis. Research has found that opioid deaths decrease in medical marijuana states.
"There's a big difference between [medical marijuana] and recreational marijuana, and I think when you see something like the opioid addiction crisis blossoming in so many states around this country, the last thing we should be doing is encouraging people," said Spicer during the briefing. "There is still a federal law that we need to abide by in terms of recreational marijuana and other drugs of that nature."
Just the threat of federal enforcement could send a chill down the spine of the adult-use industry, which just welcomed eight more states into the fold through voter-approved ballot measures on Election Day in November 2016.
But the question is, as more than half of all states now have state laws allowing for medical marijuana and/or adult-use marijuana markets, and the industry has created approximately 150,000 jobs and brought in almost $7 billion in revenue in 2016, can the industry be pushed into the black market again? A recent report by New Frontier Data forecasts the industry to create 300,000 more jobs by 2020.
"I don't think it's realistic for Trump to wage an all-out war against recreational marijuana," says Aaron Herzberg of CalCann Holdings, a portfolio of cannabis companies and brands in California. "Eight states now allow for recreational marijuana, and California, the largest of those states, is in the middle of implementing and rolling out these laws. Colorado already generates over $200 million in annual revenue from recreational marijuana. Peter Thiel, one of Trump's advisers from Silicon Valley, has heavily invested in marijuana. My guess is that this is saber-rattling."
Back in November 2016, John Hudak, a senior fellow at the Brookings Institution, said that if Sessions became attorney general, he would have the power to rescind the Department of Justice memos issued under the Obama administration that have allowed marijuana companies to exist without fear of DEA raids. (The Ogden and Cole memos assure the industry that federal law enforcement agents will not step in as long as businesses follow the rules and do not act as fronts for organized crime, do not sell to kids, and avoid other federal enforcement priorities.) If Sessions rescinds the memos, which are non-binding, the industry should be afraid.
"Jeff Sessions could have an existential and devastating effect on the marijuana industry as we know it," said Hudak. "His views are opposed to reform and opposed to legalization."
The National Cannabis Industry Association, a trade group, said in a statement that it is disappointed with the White House's announcement of a crackdown on adult use.
"It would be a mistake for the Department of Justice to overthrow the will of the voters and state governments who have created carefully regulated adult-use marijuana programs. It would represent a rejection of the values of economic growth, limited government, and respect for federalism that Republicans claim to embrace," said NCIA executive director Aaron Smith in a statement. "These programs are working. Marijuana interdictions at the Mexican border are down substantially, youth use has not increased in states with legal access to cannabis, and responsible cannabis businesses are contributing tens of thousands of jobs and hundreds of millions of dollars in economic impact to their communities."
Spicer's comments regarding a crackdown came only hours after Quinnipiac University released a new poll, which found that 71 percent of all Americans would oppose efforts to enforce federal marijuana laws in states with legalization.
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In a historic move, the U.S. Drug Enforcement Agency granted approval for a nonprofit to study marijuana's medical benefits on military veterans suffering from combat-related psychological disorders.
The Multidisciplinary Association for Psychedelic Studies (MAPS), a California-based nonprofit that studies medical uses of psychotropic drugs, will conduct the clinical trial, which will be a double-blind, placebo-controlled trial using the whole plant (not an extract or pill version). The trial is the first in U.S. history to receive full approval from the DEA and FDA.
The study will examine whether medical marijuana can treat Post-Traumatic Stress Disorder in 76 U.S. military veterans. The veterans have treatment-resistant PTSD and haven't found relief from other medications. The study will look into how different strains and doses of marijuana can benefit the veterans and look into potential side effects, a press release from MAPS says.
The trial intends to develop "smoked botanical marijuana into a legal prescription drug" approved by the FDA, MAPS says in a statement.
MAPS received a $2.16 million grant from Colorado's Department of Public Health and Environment (CDPHE) to conduct the trial.
"We have been working towards approval since we opened the Investigational New Drug Application (IND) with the FDA in 2010," said Amy Emerson, executive director and director of clinical research for the MAPS Public Benefit Corporation, in a release. "We are thrilled to see this study overcome the hurdles of approval so we can begin gathering the data. This study is a critical step in moving our botanical drug development program forward at the federal level to gather information on the dosing, risks, and benefits of smoked marijuana for PTSD symptoms."
MAPS, which was founded in 1986, has raised over $36 million for psychedelic therapy and research and education in marijuana's medical benefits.