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Understanding Cannabinoids: CBN vs CBD

While there are many cannabinoids that may enhance the therapeutic effects of hemp products, the most common renowned product is the phytochemicals in the Cannabis genus that contain the tetrahydrocannabinol or THC. This is the substance that is responsible for all of the psychoactive effects of cannabis. CBD has long been associated with the variety that offers up the best help benefits without offering up the high that the THC gives to users.

While the CBD may not be the feature that is in all of the hemp products, it’s a by-product of the THC. Hemp Genix, Wholesale CBD Oil in Lockhart, has 80% purity compared to competitors at 17%-40%.  The CBN doesn’t bind to the body’s cannabinoid receptors like the THC does. It’s long been known to give a stronger sedative effect when it’s used in combination with the THC.

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At Hemp Genix, all of our products are made with 100 percent USA, Zero THC and 80 percent purity Wholesale full-spectrum CBD oil in Lockhart. This is carefully derived from a variety of cultivars of hemp which contain an abundance of cannabinoids.

A lot of people are very familiar with CBD or Cannabidiol. This is found in highly concentrated amounts in a variety of products. However, there are lots of cannabinoids that are found in hemp. These have shown a variety of benefits in studies. All of our products offer you full-spectrum hemp oil. This also includes all of our cannabinoids that are found in the plant. We don’t want you to miss out on any of the benefits.

 

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This is the most abundant cannabinoid in the hemp oil. It makes up 90 percent of the content of cannabinoid. It’s non-psychoactive and the focus is on how it benefits the body via the hemp oil. It has minimal affinity for CB1 or CB2 receptors. The main focus on interaction is in the endocannabinoid system and it acts as an indirect antagonist toward the cannabinoid antagonists. This, in turn, may allow the CBD to temper the high that is caused through the THC. Wholesale CBD Oil in Lockhart from Hemp Genix are over 80 percent pure and CBD makes up the majority of the Oils weight. Industry averages and nearly all of the other products with cannabinoids and brands average in at 17 to 40 percent purity.

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What’s The Difference Between CBD And CBN?

Cannabis has a number of cannabinoids in which the most abundant are the levels of THC. There are 9 tetrahydrocannabinol as well as CBD and CBN. This is the active ingredient that makes you high. The THC is in the plant and the CBD is the precursor and the CBN is the metabolite of the THC. As the cannabis ages, the THC level breaks down into the CBN.

 

This also leads researchers to believe that the CBD might give some protection against ecstasy-derived neurotoxins or long-term depletion of the serotonergic receptions. While this is still speculation, it’s investigating further. The CBD is usually present in significant enough quantities in such products as hashish or cannabis resins. However,r it’s also in the herbal cannabis referred to as skunk in smaller amounts.

Overall, the CBN is a great cannabinoid that offers up a varied range of therapeutic applications that work together with the rest of the “team” in order to offer up the best possible results. Clearly, more clinical trials are required to see how else it can benefit patients.

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Editor's note: This article is part of Inc.'s 2015 Best Industries report.

In the beginning, Pete Williams grew medical marijuana in his basement. He grew strains with names like White Widow and Sour Diesel, and it was good. Eventually, Pete's older brother Andy joined him and the business soon became too big for the basement. Five years later, Medicine Man is one of the largest and most successful cannabis dispensaries in the state of Colorado. With two retail locations, one in Denver and the other in Aurora, the company produced 7,000 pounds of pot and made $8 million in revenue in 2014. 

The Williams brothers--along with their sister, Sally Vander Veer, who helped with Medicine Man's launch and came on as CFO in 2013--are one of the many success stories in Colorado's $1.5 billion legal weed industry. According to a report by Convergex Group, the state's 300 licensed marijuana businesses generated $350 million in revenue in 2014, a figure that's expected to grow by 20 percent this year. 

Out of the basement.

In 2008, the recession crippled Pete's custom tile business. After 18 years of marriage, he and his wife got divorced, and he needed to make money to support his two children. A friend gave him 16 pot plants, each one small enough to fit inside a Dixie cup, and told him there's good money in "caregiving," or growing weed for medical patients. A born tinkerer, Pete built a complex grow system incorporating hydroponics and aeroponics techniques. That first year, he made $100,000 out of his basement selling to dispensaries.

President Obama declared state-legalized medical cannabis a "low priority" for law enforcement the following year. That's when Andy came down to the basement with a plan. "I'll be the businessman and you be the green thumb," Andy, now the president and chief executive of Medicine Man, remembers telling Pete.

With a loan of just over a half-million dollars from their mother, the brothers leased a 20,000-square-foot space in a warehouse in Denver's Montbello neighborhood and built a state-of-the-art hydroponics-based system. At that time, the brothers were selling wholesale, but in December 2010 a new law was enacted requiring cannabis growers to sell their product directly to customers. Andy and Pete built a dispensary in the front of the warehouse and ceased their wholesale business.  

By 2013 Medicine Man was able to buy the warehouse and had generated $4 million in revenue. But with the legalization of recreational marijuana on the horizon, Andy knew the company needed to raise more money to expand their grow facility and up production in preparation for a spate of new customers. He pitched cannabis angel investor network ArcView Group in California and secured $1.6 million in funding. 

"Andy was the right entrepreneur at the right time for an investment opportunity. At the end of the day, it's clear Andy thought all the way through the pieces of the puzzle," says ArcView CEO Troy Dayton. (Neither Dayton nor ArcView is a Medicine Man investor.) "In a nascent industry, companies get traction not only when they are early but when they are a great business and composed of great people--Andy has both." 

On January 1, 2014, the first day sales of recreational marijuana were officially legal, Medicine Man sold 15 pounds of pot and made close to $100,000. Meanwhile Pete, Andy, and Sally have been looking ahead to a day when cannabis becomes legal nationwide. To ensure another revenue stream, the trio created Medicine Man Technologies, a consulting firm that offers turnkey packages to entrepreneurs who want to start pot business. Medicine Man Technologies, which has helped clients build medical facilities in New York, Illinois, Florida, and Nevada, will become a publicly traded company on the over-the-counter market this summer.

The challenges of being a potpreneur. 

In spite of the safe haven Colorado has created, pot businesses still face at least two major hurdles: First, until major banks decide it's safe to bring on marijuana clients, the businesses must deal exclusively in cash. Medicine Man, which says it brought in $50,000 a day in December, has had to invest heavily in security measures. Its two locations are equipped with a total of more than 100 cameras trained inside and out, as well as bulletproof glass and doors. The company has also hired security company Blue Line Protection Group to supply armed guards for the dispensaries and warehouses, and armored trucks to run money from the safe to pay bills, the government, and vendors. 

Cannabusinesses also face extremely high taxes, in some cases exceeding 50 percent. But thanks to Pete's super-efficient grow operation, which produces a gram of marijuana for the comparatively low cost of $2.50, Medicine Man has been able to slash prices for the customer while staying profitable--so even after the state takes its cut, the company's margins are 30 to 40 percent, Sally says. 

Exit strategy.

It's easy to look at the Williamses, or watch them on MSNBC's reality show Pot Barons of Colorado, and believe they have the life. The trio seem to be sitting on top of the Mile High City's legal weed industry, but they didn't get up there without personal sacrifice. For example, Andy's decision to give up a stable job to launch Medicine Man cost him his marriage.  

"One thing people don't understand is that the entrepreneurs who started the industry in Denver are pioneers in the truest sense. What it takes to be a pioneer is vision, the ability to see something, and the courage to go after it despite the risks," he says. "The risks weren't just about money--they were about our reputations, our freedom, and our families. People risked everything for it."

After years of dealing with all those risks and sacrifices, the Williamses now say they're ready to put their feet up and enjoy the rewards of building the "Costco of marijuana." The siblings are currently in talks with private equity firms regarding an acquisition. They put the current value of the 80-employee business at $30 million, and say it will bring in $15 to $18 million in revenue in 2015.

"We began this whole thing with an end game in mind," Pete says. "We're all in our late 40s and we don't want to work for the rest of our lives." 

He adds that they're willing to sell their majority stake, but they'd like to hang on to 5 to 10 percent. "If we don't sell out, [an acquiring company] will buy our biggest competitor," he says. "If we hook up with the right people, Medicine Man can be a household name like Pepsi or Coke. [People will say,] 'Go get me a pack a Medicine Mans, honey.'"

Why You Need a Workplace Marijuana Policy

The Department of Justice could crack down on adult-use marijuana, or what's referred to as "recreational marijuana," and enforce federal law regulating cannabis as an illegal substance, the Trump administration said during a briefing on Thursday.

White House Press Secretary Sean Spicer, during his daily press briefing, said the Department of Justice will be the lead on what Spicer referred to as "greater enforcement" of federal law concerning adult-use marijuana. The Justice Department's new head, former Alabama Senator Jeff Sessions, is staunchly opposed to marijuana legalization.

Medical marijuana, Spicer said, is safe from enforcement because of the Rohrabacher-Farr Amendment, which prohibits the DOJ from spending money to prevent states from implementing medical marijuana laws, and because President Trump "understands" how patients with terminal illnesses find "comfort" with medical cannabis. Spicer said Trump and the DOJ have drawn a line in the sand: medical marijuana on one side and adult-use on the other. The White House says adult-use marijuana would exacerbate the opioid epidemic, which is killing 40,000 Americans a year, according the Center for Disease Control. Studies have found that legal marijuana could help stem the opioid crisis. Research has found that opioid deaths decrease in medical marijuana states.

"There's a big difference between [medical marijuana] and recreational marijuana, and I think when you see something like the opioid addiction crisis blossoming in so many states around this country, the last thing we should be doing is encouraging people," said Spicer during the briefing. "There is still a federal law that we need to abide by in terms of recreational marijuana and other drugs of that nature."

Just the threat of federal enforcement could send a chill down the spine of the adult-use industry, which just welcomed eight more states into the fold through voter-approved ballot measures on Election Day in November 2016.

But the question is, as more than half of all states now have state laws allowing for medical marijuana and/or adult-use marijuana markets, and the industry has created approximately 150,000 jobs and brought in almost $7 billion in revenue in 2016, can the industry be pushed into the black market again? A recent report by New Frontier Data forecasts the industry to create 300,000 more jobs by 2020.

"I don't think it's realistic for Trump to wage an all-out war against recreational marijuana," says Aaron Herzberg of CalCann Holdings, a portfolio of cannabis companies and brands in California. "Eight states now allow for recreational marijuana, and California, the largest of those states, is in the middle of implementing and rolling out these laws. Colorado already generates over $200 million in annual revenue from recreational marijuana. Peter Thiel, one of Trump's advisers from Silicon Valley, has heavily invested in marijuana. My guess is that this is saber-rattling."

Back in November 2016, John Hudak, a senior fellow at the Brookings Institution, said that if Sessions became attorney general, he would have the power to rescind the Department of Justice memos issued under the Obama administration that have allowed marijuana companies to exist without fear of DEA raids. (The Ogden and Cole memos assure the industry that federal law enforcement agents will not step in as long as businesses follow the rules and do not act as fronts for organized crime, do not sell to kids, and avoid other federal enforcement priorities.) If Sessions rescinds the memos, which are non-binding, the industry should be afraid.

"Jeff Sessions could have an existential and devastating effect on the marijuana industry as we know it," said Hudak. "His views are opposed to reform and opposed to legalization."

The National Cannabis Industry Association, a trade group, said in a statement that it is disappointed with the White House's announcement of a crackdown on adult use.

"It would be a mistake for the Department of Justice to overthrow the will of the voters and state governments who have created carefully regulated adult-use marijuana programs. It would represent a rejection of the values of economic growth, limited government, and respect for federalism that Republicans claim to embrace," said NCIA executive director Aaron Smith in a statement. "These programs are working. Marijuana interdictions at the Mexican border are down substantially, youth use has not increased in states with legal access to cannabis, and responsible cannabis businesses are contributing tens of thousands of jobs and hundreds of millions of dollars in economic impact to their communities."

Spicer's comments regarding a crackdown came only hours after Quinnipiac University released a new poll, which found that 71 percent of all Americans would oppose efforts to enforce federal marijuana laws in states with legalization.


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